Medical Scientist Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nat Chem Biol. 2010 Feb;6(2):102-4. doi: 10.1038/nchembio.282. Epub 2009 Dec 20.
Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming.
小分子可以在体内控制细胞命运，并且可以定向诱导所需的细胞类型，为再生医学中的基于移植的方法提供了一种有吸引力的替代方案。我们已经在本来只产生精子的成年秀丽隐杆线虫中用化学方法诱导产生了功能性卵子。这些发现表明，化学方法治疗性细胞重编程可能是可行的，并为分析体内细胞重编程的分子机制提供了一个强大的平台。
