The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver BC, V6T 1Z3, Canada.
Nat Cell Biol. 2010 Feb;12(2):153-63. doi: 10.1038/ncb2015. Epub 2010 Jan 17.
Efficient tissue regeneration is dependent on the coordinated responses of multiple cell types. Here, we describe a new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage. Transplantation of purified FAPs results in the generation of ectopic white fat when delivered subcutaneously or intramuscularly in a model of fatty infiltration, but not in healthy muscle, suggesting that the environment controls their engraftment. These cells are quiescent in intact muscle but proliferate efficiently in response to damage. FAPs do not generate myofibres, but enhance the rate of differentiation of primary myogenic progenitors in co-cultivation experiments. In summary, FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors.
有效的组织再生依赖于多种细胞类型的协调反应。在这里，我们描述了一种存在于肌肉组织中的成纤维/脂肪生成祖细胞（FAP）的新亚群，但它来自于一个不同的发育谱系。在脂肪浸润模型中，将纯化的 FAP 移植到皮下或肌肉内会导致异位白色脂肪的产生，但不会在健康肌肉中产生，这表明环境控制着它们的植入。这些细胞在完整的肌肉中处于静止状态，但在受到损伤时会有效地增殖。FAP 不会产生肌纤维，但在共培养实验中会增强原代成肌祖细胞的分化速度。总之，FAP 在损伤后会扩张，为增殖的成肌祖细胞提供短暂的促分化信号来源。
