MK2 signaling: lessons on tissue specificity in modulation of inflammation.

MK2 is a promising candidate for treating inflammation. Mice deficient in MK2 were studied in models of inflammation to see whether MK2 could be a useful target in inflammatory skin disease. Surprisingly, MK2 played only a minor role in skin inflammation, indicating that modulation of cell signaling gives different results depending on the models of inflammation and target organs that are studied.