Molecular Inflammation Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, NO-9037 Tromsø, Norway.
Genes (Basel). 2013 Mar 26;4(2):101-33. doi: 10.3390/genes4020101.
Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and convert a plethora of extracellular signals by three consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK kinase, and a MAPK. In turn MAPKs phosphorylate substrates, including other protein kinases referred to as MAPK-activated protein kinases (MAPKAPKs). Eleven mammalian MAPKAPKs have been identified: ribosomal-S6-kinases (RSK1-4), mitogen- and stress-activated kinases (MSK1-2), MAPK-interacting kinases (MNK1-2), MAPKAPK-2 (MK2), MAPKAPK-3 (MK3), and MAPKAPK-5 (MK5). The role of these MAPKAPKs in inflammation will be reviewed.
丝裂原活化蛋白激酶（MAPK）途径参与多种细胞过程，包括增殖、分化、凋亡、细胞存活、细胞迁移、代谢、应激反应和炎症。MAPK 途径通过涉及 MAPK 激酶激酶、MAPK 激酶和 MAPK 的三个连续磷酸化事件来传递和转化大量的细胞外信号。反过来，MAPKs 磷酸化底物，包括其他蛋白激酶，称为 MAPK 激活蛋白激酶（MAPKAPKs）。已经鉴定出 11 种哺乳动物 MAPKAPKs：核糖体 S6 激酶（RSK1-4）、有丝分裂原和应激激活激酶（MSK1-2）、MAPK 相互作用激酶（MNK1-2）、MAPKAPK-2（MK2）、MAPKAPK-3（MK3）和 MAPKAPK-5（MK5）。本文将综述这些 MAPKAPKs 在炎症中的作用。
