Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Ross 965, Baltimore, MD 21205, USA.
Immunol Res. 2010 Jul;47(1-3):78-85. doi: 10.1007/s12026-009-8140-7.
Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.
肾缺血/再灌注损伤（IRI）是住院患者中常见且严重的问题。免疫细胞迁移和白细胞-内皮细胞黏附加剧了肾 IRI。T 淋巴细胞在 IRI 中具有重要的免疫调节作用，这一点已得到阐明。调节性 T 细胞是一种淋巴细胞亚群，最近的研究表明，它在 IRI 的早期损伤以及后期修复中均发挥保护作用。免疫系统在肾 IRI 期间还参与远处器官的效应。关注肾 IRI 免疫方面的研究使人们发现了有前途的新型治疗和诊断方法。
