Scheel Paul J, Liu Manchang, Rabb Hamid
Nephrology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Kidney Int. 2008 Oct;74(7):849-51. doi: 10.1038/ki.2008.390.
The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.
尽管透析技术有所进步，但急性肾损伤（AKI）的高死亡率仍促使人们重新认识到AKI对远处器官功能障碍的影响。机制研究表明，AKI会导致肺血管通透性增加、可溶性和细胞炎症以及盐和水通道失调。AKI还会影响大脑、心脏、肝脏、骨髓和胃肠道。克莱因等人现在证明，白细胞介素-6是AKI诱导的肺部变化的直接介质。
