Singer Alfred, Adoro Stanley, Park Jung-Hyun
Experimental Immunology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA.
Nat Rev Immunol. 2008 Oct;8(10):788-801. doi: 10.1038/nri2416.
Following successful gene rearrangement at alphabeta T-cell receptor (TCR) loci, developing thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection event, which is known as positive selection, to identify cells that express TCRs with potentially useful ligand specificities. Positively selected thymocytes must then differentiate into either CD4(+) helper T cells or CD8(+) cytotoxic T cells, a crucial decision known as CD4/CD8-lineage choice. In this Review, we summarize recent advances in our understanding of the cellular and molecular events involved in lineage-fate decision and discuss them in the context of the major models of CD4/CD8-lineage choice.
在αβ T细胞受体（TCR）基因座成功进行基因重排后，发育中的胸腺细胞同时表达CD4和CD8共受体，并经历一个生死抉择的选择事件，即阳性选择，以识别表达具有潜在有用配体特异性的TCR的细胞。然后，经过阳性选择的胸腺细胞必须分化为CD4(+)辅助性T细胞或CD8(+)细胞毒性T细胞，这一关键决定被称为CD4/CD8谱系选择。在本综述中，我们总结了我们对谱系命运决定所涉及的细胞和分子事件的理解的最新进展，并在CD4/CD8谱系选择的主要模型背景下进行讨论。
