Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, CHU Sart-Tilman, Liège, Belgium.
Cell Mol Life Sci. 2010 Apr;67(8):1255-64. doi: 10.1007/s00018-009-0252-7. Epub 2010 Jan 16.
Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
赖氨酸乙酰化是一种翻译后修饰，通过靶向核内的组蛋白和各种转录因子，对基因转录进行关键调控。最近的研究报告还表明，许多位于核外的蛋白质也发生了乙酰化，这种修饰对它们的功能有深远的影响。本文综述了核外乙酰化底物以及催化这些修饰的乙酰转移酶和去乙酰化酶的最新研究进展。蛋白质乙酰化正成为许多生理过程（如迁移、代谢和衰老）以及病理情况（如癌症和神经退行性疾病）中关键蛋白调控的主要机制。
