Sadoul Karin, Wang Jin, Diagouraga Boubou, Khochbin Saadi
INSERM, U823, Institut Albert Bonniot, Université Joseph Fourier Grenoble 1, 38700 Grenoble, France.
J Biomed Biotechnol. 2011;2011:970382. doi: 10.1155/2011/970382. Epub 2010 Nov 28.
Reversible posttranslational modification of internal lysines in many cellular or viral proteins is now emerging as part of critical signalling processes controlling a variety of cellular functions beyond chromatin and transcription. This paper aims at demonstrating the role of lysine acetylation in the cytoplasm driving and coordinating key events such as cytoskeleton dynamics, intracellular trafficking, vesicle fusion, metabolism, and stress response.
许多细胞或病毒蛋白内部赖氨酸的可逆翻译后修饰，正逐渐成为控制染色质和转录以外多种细胞功能的关键信号传导过程的一部分。本文旨在证明赖氨酸乙酰化在细胞质中驱动和协调关键事件（如细胞骨架动力学、细胞内运输、囊泡融合、代谢和应激反应）中的作用。
