Finkel Toren, Deng Chu-Xia, Mostoslavsky Raul
Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Nature. 2009 Jul 30;460(7255):587-91. doi: 10.1038/nature08197.
The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.
沉默调节蛋白是一类高度保守的依赖烟酰胺腺嘌呤二核苷酸（NAD⁺）的酶家族，可调节低等生物的寿命。最近，哺乳动物的沉默调节蛋白已与越来越多的活动联系在一起，这些活动包括细胞应激抗性、基因组稳定性、肿瘤发生和能量代谢。在这里，我们综述了沉默调节蛋白生物学的最新进展、这些蛋白质在各种与年龄相关疾病中的作用，以及这个酶家族的活性以某种方式调节我们寿命长短这一诱人的观点。
