Department of Radiology, Maltepe University School of Medicine, Maltepe, Istanbul, Turkey.
Radiol Med. 2010 Apr;115(3):434-41. doi: 10.1007/s11547-010-0513-4. Epub 2010 Jan 15.
We aimed to analyse the influence of mammographic breast density on background enhancement (BE) at magnetic resonance (MR) mammography in pre- and postmenopausal women. In addition, we questioned predictability of contrast-enhancement dynamics of normal fibroglandular tissue (NFT) at MR mammography according to mammographic breast density.
Twenty-six patients (mean age 51.54+/-11.5 years; range 37-79 years) who underwent both MR mammography and conventional mammography were included in this retrospective study. Fourteen patients were premenopausal and 12 were postmenopausal. The ethics committee of our institution approved the study. The mammograms were retrospectively reviewed for overall breast density according to the four-point scale (I-IV) of the Breast Imaging Reporting and Data System (BI-RADS) classification. Two radiologists, who were unaware of the clinical data, separately assessed the MR mammography images. Images were assessed for enhancement kinetic features (enhancement kinetic curve and the early-phase enhancement rate) and BE. MR mammography and conventional mammography findings were compared according to BI-RADS breast density category and menopausal status.
Percentage of increased signal intensity values during the first minute did not change according to mammographic breast density, and the mean early-phase enhancement rate scores were similar among breast density groups (p=0.942). There was no significant difference between pre- and postmenopausal groups. Enhancement kinetic features of the different groups based on BI-RADS breast density category and menopausal status were similar. There was no correlation between breast density and BE in either premenopausal (p=0.211) or in postmenopausal (p=0.735) groups.
We determined no correlation between mammographic breast density and so-called BE in MR mammography in either premenopausal or postmenopausal women. NFT at MR mammography cannot be predicted on the basis of mammographic breast density.
本研究旨在分析乳腺 X 线摄影中乳房密度对绝经前后妇女磁共振（MR）乳腺摄影背景增强（BE）的影响。此外，我们还探讨了 MR 乳腺摄影中正常纤维腺体组织（NFT）对比增强动力学是否可根据乳腺 X 线摄影乳房密度进行预测。
本回顾性研究纳入 26 例（平均年龄 51.54+/-11.5 岁；范围 37-79 岁）同时接受 MR 乳腺摄影和常规乳腺摄影的患者。14 例为绝经前患者，12 例为绝经后患者。本机构伦理委员会批准了这项研究。回顾性地根据乳腺影像报告和数据系统（BI-RADS）分类的 4 分制（I-IV）评估所有乳腺的总体密度。两名放射科医生在不了解临床数据的情况下分别评估了 MR 乳腺摄影图像。评估了图像的增强动力学特征（增强动力学曲线和早期增强率）和 BE。根据 BI-RADS 乳腺密度类别和绝经状态比较了 MR 乳腺摄影和常规乳腺摄影的结果。
在第 1 分钟内信号强度值增加的百分比与乳腺密度无关，乳腺密度组之间的早期增强率评分相似（p=0.942）。绝经前和绝经后组之间无显著差异。基于 BI-RADS 乳腺密度类别和绝经状态的不同组之间的增强动力学特征相似。在绝经前（p=0.211）或绝经后（p=0.735）组中，乳腺密度与 BE 之间均无相关性。
本研究在绝经前或绝经后妇女的 MR 乳腺摄影中均未发现乳腺密度与所谓的 BE 之间存在相关性。MR 乳腺摄影中 NFT 不能根据乳腺密度进行预测。
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