Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil.
Muscle Nerve. 2010 Feb;41(2):257-60. doi: 10.1002/mus.21559.
In this study we investigated energy metabolism in the mdx mouse brain.To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex II activity in all structures. There was an increase in Complex III activity in striatum and a decrease in Complex IV activity in prefrontal cortex and striatum. Mitochondrial creatine kinase activity was increased in hippocampus, prefrontal cortex, cortex, and striatum. Our results indicate that there is energy metabolism dysfunction in the mdx mouse brain.
在这项研究中，我们研究了 mdx 小鼠大脑中的能量代谢。为此，分析了前额叶皮层、小脑、海马体、纹状体和大脑皮层。所有结构中的复合物 I 活性降低，但复合物 II 活性没有降低。纹状体中的复合物 III 活性增加，而前额叶皮层和纹状体中的复合物 IV 活性降低。线粒体肌酸激酶活性在海马体、前额叶皮层、大脑皮层和纹状体中增加。我们的结果表明，mdx 小鼠大脑存在能量代谢功能障碍。
