p53、c-erbB-2 和 Ki67 在肠上皮化生和胃癌中的表达。
Expression of p53, c-erbB-2 and Ki67 in intestinal metaplasia and gastric carcinoma.
机构信息
Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
出版信息
World J Gastroenterol. 2010 Jan 21;16(3):339-44. doi: 10.3748/wjg.v16.i3.339.
AIM
To compare two types of classification of intestinal metaplasia (IM) of the stomach and to explore their relationship to gastric carcinoma.
METHODS
Forty-seven cases of gastric IM were classified into type I, type II or type III according to mucin histochemical staining and compared with a novel classification in which the specimens were classified into simple IM (SIM) or atypical IM according to polymorphism in terms of atypical changes of the metaplastic epithelium. Forty-seven IM and thirty-seven gastric carcinoma samples were stained for p53, c-erbB-2 and Ki67 proteins by Envision immunohistochemical technique.
RESULTS
There were no significant differences in the expression of p53 and c-erbB-2 among type I, type II, type III IM and gastric carcinomas. The positive expression rate of Ki67 was significantly higher in gastric carcinomas than in type I IM while no significant Ki67 expression differences were observed among type II, type III IM and gastric carcinomas. The expression of p53, c-erbB-2 and Ki67 proteins in 20 SIM, 27 Atypical IM and 37 gastric carcinomas showed significant differences between SIM and gastric carcinomas while no significant differences were observed between Atypical IM and gastric carcinomas.
CONCLUSION
Atypical IM may better reveal the precancerous nature of IM and could be a helpful indicator in the clinical follow up of patients.
目的
比较胃黏膜肠上皮化生（IM）的两种分类方法，并探讨其与胃癌的关系。
方法
根据黏蛋白组织化学染色，将 47 例胃 IM 分为 I 型、II 型或 III 型，并与一种新的分类方法进行比较，根据异型增生上皮的多态性，将标本分为单纯 IM（SIM）或非典型 IM。采用 Envision 免疫组织化学技术对 47 例 IM 和 37 例胃癌标本进行 p53、c-erbB-2 和 Ki67 蛋白染色。
结果
I 型、II 型、III 型 IM 和胃癌中 p53 和 c-erbB-2 的表达无显著差异。Ki67 在胃癌中的阳性表达率明显高于 I 型 IM，而 II 型、III 型 IM 与胃癌之间 Ki67 的表达无显著差异。20 例 SIM、27 例非典型 IM 和 37 例胃癌中 p53、c-erbB-2 和 Ki67 蛋白的表达在 SIM 和胃癌之间存在显著差异，而非典型 IM 和胃癌之间无显著差异。
结论
非典型 IM 可能更好地揭示 IM 的癌前性质，可作为临床随访患者的一个有用指标。
Zotero 插件