参与胆石形成和辣椒素代谢的遗传变异与智利女性胆囊癌风险的关系。
Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.
机构信息
Division of Social and Environmental Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
出版信息
World J Gastroenterol. 2010 Jan 21;16(3):372-8. doi: 10.3748/wjg.v16.i3.372.
Abstract
AIM
To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).
METHODS
A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffin block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman SNP Genotyping Assays or Custom Taqman SNP Genotyping Assays.
RESULTS
The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR: 0.14, 95% CI: 0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR: 5.04, 95% CI: 1.43-17.8).
CONCLUSION
Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs708272 polymorphisms may be related to the risk of developing GBC in Chilean women.
摘要
目的
确定与胆石形成和辣椒素（辣椒的一种辛辣成分）代谢相关的遗传变异对胆囊癌（GBC）风险的影响。
方法
本研究纳入了 57 名 GBC 患者、119 名胆石症患者和 70 名对照。使用标准商业试剂盒从他们的血液或石蜡块样本中提取 DNA。使用 Taqman SNP 基因分型检测或定制 Taqman SNP 基因分型检测来检测遗传变异的状态。
结果
载脂蛋白 B rs693 多态性的非祖先 T/T 基因型与 GBC 的风险降低相关（OR：0.14，95%CI：0.03-0.63）。胆固醇酯转移蛋白（CETP）rs708272 多态性的 T/T 基因型与 GBC 的风险增加相关（OR：5.04，95%CI：1.43-17.8）。
结论
涉及胆石形成的遗传变异，如载脂蛋白 B rs693 和 CETP rs708272 多态性，可能与智利女性发生 GBC 的风险有关。
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