Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Diabetes Technol Ther. 2010 Jan;12(1):35-9. doi: 10.1089/dia.2009.0084.
This study examined parental attitudes towards overnight closed-loop (CL) glucose control in children and young people with type 1 diabetes (T1D).
Twelve families recruited by the INsulin PUmp Therapy group (INPUT), a U.K. patient/carer-led support group for people with T1D, attended a focus meeting on CL. The concept of CL was explained, and clinical results and plans regarding the Artificial Pancreas Project at Cambridge were presented. Participants completed a questionnaire to evaluate parental feelings about T1D management and attitudes towards overnight CL insulin delivery.
Nineteen parents (12 mothers and seven fathers) anonymously completed the questionnaire. Main concerns about diabetes were related to long-term complications (84%) and hypoglycemia (16%). Achieving good glucose control represented major challenge for carers (83%) with nighttime being the most difficult period to manage (56%), worrying most parents (71%) particularly because of fear of hypoglycemia (33%). The development of CL to manage diabetes was welcomed by all parents (100%) with 95% happy for their child to wear a continuous glucose monitor together with an insulin pump. All parents were ready to respond to additional alarms at night with 90% parents not worried about their child's overnight insulin delivery being controlled by a computer.
Selected parents of children with T1D who are already insulin pump users express implied trust in the technology for overnight CL insulin delivery. Nighttime blood glucose control is the biggest challenge and concern for parents, and the development of a commercially available overnight CL system may be an important goal.
本研究调查了父母对 1 型糖尿病（T1D）儿童和青少年进行夜间闭环（CL）血糖控制的态度。
通过英国糖尿病患者/护理人员领导的支持组织 INsulin PUmp Therapy 小组（INPUT）招募了 12 个家庭，他们参加了关于 CL 的焦点会议。解释了 CL 的概念，并介绍了剑桥人工胰腺项目的临床结果和计划。参与者完成了一份问卷，以评估父母对 T1D 管理的感受以及对夜间 CL 胰岛素输送的态度。
19 位父母（12 位母亲和 7 位父亲）匿名填写了问卷。对糖尿病的主要担忧与长期并发症（84%）和低血糖（16%）有关。护理人员认为实现良好的血糖控制是一项重大挑战（83%），夜间是最难管理的时期（56%），最让父母担心（71%），特别是因为担心低血糖（33%）。所有父母都欢迎开发 CL 来管理糖尿病（100%），95%的父母希望他们的孩子佩戴连续血糖监测仪和胰岛素泵。所有父母都准备好在夜间对额外的警报做出反应，90%的父母不担心他们的孩子的夜间胰岛素输送会由计算机控制。
已经使用胰岛素泵的 T1D 儿童的选定父母对夜间 CL 胰岛素输送的技术表示隐含信任。夜间血糖控制是父母最大的挑战和关注点，开发商业化的夜间 CL 系统可能是一个重要目标。
