Translational systems biology of inflammation and healing.

Personalized medicine is a major goal for the future of healthcare, and we suggest that computational simulations are necessary in order to achieve it. Inflammatory diseases, both acute and chronic, represent an area in which personalized medicine is especially needed, given the high level of individual variability that characterizes these diseases. We have created such simulations, and have used them to gain basic insights into the inflammatory response under baseline, gene-knockout, and drug-treated experimental animals; for in silico experiments and clinical trials in sepsis, trauma, and wound healing; and to create patient-specific simulations in polytrauma, traumatic brain injury, and vocal fold inflammation. Since they include both circulating and tissue-level inflammatory mediators, these simulations transcend typical cytokine networks by associating inflammatory processes with tissue/organ damage via tissue damage/dysfunction. We suggest that computational simulations are the cornerstone of Translational Systems Biology approaches for inflammatory diseases.