Department of Surgery; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Wound Repair Regen. 2010 Jan-Feb;18(1):3-7. doi: 10.1111/j.1524-475X.2009.00566.x.
Personalized medicine is a major goal for the future of healthcare, and we suggest that computational simulations are necessary in order to achieve it. Inflammatory diseases, both acute and chronic, represent an area in which personalized medicine is especially needed, given the high level of individual variability that characterizes these diseases. We have created such simulations, and have used them to gain basic insights into the inflammatory response under baseline, gene-knockout, and drug-treated experimental animals; for in silico experiments and clinical trials in sepsis, trauma, and wound healing; and to create patient-specific simulations in polytrauma, traumatic brain injury, and vocal fold inflammation. Since they include both circulating and tissue-level inflammatory mediators, these simulations transcend typical cytokine networks by associating inflammatory processes with tissue/organ damage via tissue damage/dysfunction. We suggest that computational simulations are the cornerstone of Translational Systems Biology approaches for inflammatory diseases.
个性化医疗是未来医疗保健的主要目标，我们认为为了实现这一目标，计算模拟是必要的。炎症性疾病，无论是急性还是慢性，都是特别需要个性化医疗的领域，因为这些疾病具有高度的个体变异性。我们已经创建了这样的模拟，并使用它们来深入了解基线、基因敲除和药物处理实验动物的炎症反应；在脓毒症、创伤和伤口愈合的计算机实验和临床试验中；以及在多发伤、创伤性脑损伤和声带炎症中创建患者特异性模拟。由于这些模拟包括循环和组织水平的炎症介质，因此它们通过将炎症过程与组织/器官损伤相关联，超越了典型的细胞因子网络，从而与组织/器官损伤/功能障碍相关联。我们认为计算模拟是炎症性疾病转化系统生物学方法的基石。
