Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Crit Care Med. 2013 Aug;41(8):2008-14. doi: 10.1097/CCM.0b013e31829a6eb4.
To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.
PubMed search and review of relevant medical literature.
Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.
Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole-organism, and population levels has suggested a positive feedback cycle of inflammation → damage → inflammation that manifests via organ-specific inflammatory switching networks. This structure may manifest as multicompartment "tipping points" that drive multiple organ dysfunction. This process may be amenable to rational inflammation reprogramming.
使临床医生熟悉应用于创伤和脓毒症的计算疾病建模的进展。
PubMed 搜索和相关医学文献的综述。
本文回顾了计算建模在创伤和脓毒症中的定义、关键方法和应用。
细胞、器官、全器官和人群水平的炎症和器官功能障碍的计算建模表明，炎症→损伤→炎症的正反馈循环通过器官特异性炎症切换网络表现出来。这种结构可能表现为多隔室“转折点”，导致多器官功能障碍。这一过程可能适合进行合理的炎症重编程。
