Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Arch Med Res. 2009 Oct;40(7):625-34. doi: 10.1016/j.arcmed.2009.09.004.
Previous published data have implicated TP53 codon 72 polymorphisms as risk factors for various cancers. Growing bodies of studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of this relationship.
We conducted a search in the relevant databases without a language limitation, covering all papers published until May 2009. The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications.
Nine studies including 1990 cases and 2074 controls were selected. Data were extracted and further analyzed using systematic meta-analyses. Results showed that no significant differences of oral cancer risk were found between individuals carrying homozygote Arg/Arg genotype and those carrying Pro/Pro genotype (OR: 0.96, 95% CI: 0.78-1.19). Likewise, no evidence indicated that individuals with Arg/Arg genotype have a significant risk of oral cancer compared with those with a combined Pro genotype (Arg/Pro+Pro/Pro) (OR: 0.98, 95% CI: 0.85-1.12). Similarly, individuals with a combined Arg genotype (Arg/Pro+Arg/Arg) do not have a marked increased or decreased susceptibility to oral cancer relative to those with homozygote Pro/Pro genotype (OR: 1.00, 95% CI: 0.83-1.21). Moreover, when stratifying for race, results were similar among Asians or Caucasians. In addition, TP53 codon 72 polymorphisms may not associate with oral cancer risks in smokers and HPV infection status.
No evidence suggests that TP53 codon 72 polymorphisms may be a risk factor for oral carcinoma.
先前的已发表数据表明 TP53 密码子 72 多态性是各种癌症的危险因素。已经有大量研究探讨了 TP53 密码子 72 多态性与口腔癌易感性之间的关系，但结果尚无定论。本研究旨在更准确地评估这种关系。
我们在相关数据库中进行了无语言限制的检索，涵盖了截至 2009 年 5 月发表的所有论文。通过有针对性的搜索获取相关文献，并根据已建立的纳入标准选择出版物。
共纳入 9 项研究，包括 1990 例病例和 2074 例对照。提取数据并进一步进行系统荟萃分析。结果显示，携带纯合 Arg/Arg 基因型和携带 Pro/Pro 基因型的个体患口腔癌的风险无显著差异（OR：0.96，95%CI：0.78-1.19）。同样，携带 Arg/Arg 基因型的个体与携带 Pro 基因型（Arg/Pro+Pro/Pro）的个体相比，患口腔癌的风险也无显著增加（OR：0.98，95%CI：0.85-1.12）。同样，携带杂合 Arg 基因型（Arg/Pro+Arg/Arg）的个体与携带纯合 Pro/Pro 基因型的个体相比，患口腔癌的易感性也没有明显增加或降低（OR：1.00，95%CI：0.83-1.21）。此外，按种族分层，亚洲人和白种人之间的结果相似。此外，TP53 密码子 72 多态性与吸烟者和 HPV 感染状态与口腔癌风险无关。
尚无证据表明 TP53 密码子 72 多态性可能是口腔癌的危险因素。
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