Zhuo Xianlu, Zhao Houyu, Chang Aoshuang, Ye Huiping, Zhou Yan, Song Yufeng, Tan Yinghui
Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Tumour Biol. 2012 Dec;33(6):2079-89. doi: 10.1007/s13277-012-0467-3. Epub 2012 Jul 31.
Cytochrome P450 (CYP) 1A1 Ile462Val (exon7) polymorphism has been suggested to be a risk factor for several cancers. Published data on its association with oral cancer risk have generated conflicting results. Our previous meta-analysis containing data from prior to Jan 2008 regarding this issue failed to find a significant association between CYP1A1 Ile462Val variation and oral cancer susceptibility. An updated meta-analysis with eligible studies for the period up to May 2012 was conducted. Separate analyses on ethnicity and source of controls were also performed. A total of 13 case-control studies comprising 1,515 cases and 2,233 controls were lastly selected for analysis. Compared with the previous meta-analysis, the overall data also failed to indicate a significant association of CYP1A1 Ile462Val polymorphism with oral cancer risk (Val/Val vs. Ile/Ile--OR = 1.46; 95 % CI = 0.96-2.24; dominant model--OR = 1.01; 95 % CI = 0.81-1.25; and recessive model--OR = 1.46; 95 % CI = 0.96-2.23). However, in the subgroup analysis by ethnicity, increased cancer risk was observed among Asians under the additive and recessive models (Val/Val vs. Ile/Ile--OR = 1.74; 95 % CI = 1.04-2.90 and recessive model-OR = 1.73; 95 % CI = 1.04-2.87), inconsistent with the previous meta-analysis. Collectively, the data of the present study suggest that CYP1A1 variant Val/Val alleles might modify the susceptibility to oral cancer among Asians. Further well-designed investigations with large sample sizes are required to confirm this conclusion.
细胞色素P450（CYP）1A1基因第462位密码子异亮氨酸（Ile）到缬氨酸（Val）的多态性（外显子7）被认为是多种癌症的一个风险因素。关于其与口腔癌风险关联的已发表数据产生了相互矛盾的结果。我们之前包含2008年1月以前关于此问题数据的荟萃分析未能发现CYP1A1基因Ile462Val变异与口腔癌易感性之间存在显著关联。我们进行了一项更新的荟萃分析，纳入了截至2012年5月的符合条件的研究。还对种族和对照来源进行了单独分析。最后共选择了13项病例对照研究，包括1515例病例和2233例对照进行分析。与之前的荟萃分析相比，总体数据也未能表明CYP1A1基因Ile462Val多态性与口腔癌风险存在显著关联（Val/Val与Ile/Ile相比——比值比[OR]=1.46；95%可信区间[CI]=0.96 - 2.24；显性模型——OR = 1.01；95%CI = 0.81 - 1.25；隐性模型——OR = 1.46；95%CI = 0.96 - 2.23）。然而，在按种族进行的亚组分析中，在相加模型和隐性模型下，亚洲人患癌风险增加（Val/Val与Ile/Ile相比——OR = 1.74；95%CI = 1.04 - 2.90，隐性模型——OR = 1.73；95%CI = 1.04 - 2.87），这与之前的荟萃分析结果不一致。总体而言，本研究数据表明CYP1A1基因变异Val/Val等位基因可能会改变亚洲人患口腔癌的易感性。需要进一步进行设计良好的大样本研究来证实这一结论。
