Kuroda Yoshiki, Nakao Hiroyuki, Ikemura Kunio, Katoh Takahiko
Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Oral Oncol. 2007 Nov;43(10):1043-8. doi: 10.1016/j.oraloncology.2006.12.001. Epub 2007 Feb 15.
The TP53 codon72 polymorphism has recently been extensively studied to determine the risk factor for carcinogenesis. However, there are few reports about the relationship between the TP53 codon72 polymorphism and oral cancer risk or post treatment prognosis. We evaluated the genotypic distribution of the TP53 codon72 polymorphism in 100 oral cancer cases and 271 non-cancer controls. There were no significant differences in the frequencies of the three genotypes (Arg/Arg, Arg/Pro, Pro/Pro) of the TP53 codon72 polymorphism between oral cancer cases and controls. However, stratifying by smoking status, we found that the adjusted odds ratio for non-smokers with the Pro/Pro genotype was significantly increased (adjusted OR=2.70, 95% confidence interval=1.07-6.82). We also found that the cases with the Pro/Pro genotype tended to have a shorter post-treatment survival compared with those with the Arg/Pro genotype (p=0.06). Our results suggest the Pro/Pro genotype of the TP53 codon72 polymorphism increases oral cancer risk in non-smokers and worsens their prognosis.
最近，人们对TP53密码子72多态性进行了广泛研究，以确定致癌的风险因素。然而，关于TP53密码子72多态性与口腔癌风险或治疗后预后之间关系的报道较少。我们评估了100例口腔癌病例和271例非癌对照中TP53密码子72多态性的基因型分布。口腔癌病例与对照之间TP53密码子72多态性的三种基因型（Arg/Arg、Arg/Pro、Pro/Pro）频率无显著差异。然而，按吸烟状况分层后，我们发现Pro/Pro基因型的非吸烟者调整后的优势比显著增加（调整后的OR=2.70，95%置信区间=1.07-6.82）。我们还发现，与Arg/Pro基因型的病例相比，Pro/Pro基因型的病例治疗后的生存期往往较短（p=0.06）。我们的结果表明，TP53密码子72多态性的Pro/Pro基因型会增加非吸烟者患口腔癌的风险并恶化其预后。
