Department of Dermatology, University of Athens, Andreas Sygros Hospital, 5 Ionos Dragoumi Street, Kaisariani, Athens, 16121, Greece.
Clin Dermatol. 2010 Jan-Feb;28(1):17-23. doi: 10.1016/j.clindermatol.2009.03.006.
Standard systemic therapeutic agents used in acne include oral antimicrobials, isotretinoin, and hormonal agents. Appropriate patient selection is the key to decide when to use hormonal agents as first-line therapy as well as to achieve optimal results. Indications of hormonal therapy in acne in girls and women include proven ovarian or adrenal hyperandrogenism, recalcitrant acne, acne not responding to repeated courses of oral isotretinoin, acne tarda, polycystic ovary syndrome, or the presence of clinical signs of hyperandrogenism such as androgenic alopecia or the presence of the seborrhea, acne, hirsutism, alopecia syndrome. We describe the hormonal agents currently available for acne treatment, discuss their indications and contraindications, and address the question of whether they may be used as a first-line therapy in acne.
痤疮的标准系统治疗药物包括口服抗菌药物、异维 A 酸和激素药物。适当的患者选择是决定何时将激素药物作为一线治疗以及实现最佳效果的关键。女性痤疮激素治疗的适应证包括已证实的卵巢或肾上腺高雄激素血症、顽固型痤疮、多次口服异维 A 酸治疗无效的痤疮、迟发性痤疮、多囊卵巢综合征或存在雄激素过多的临床体征，如雄激素性脱发或皮脂溢、痤疮、多毛症、脱发综合征。我们描述了目前可用于痤疮治疗的激素药物，讨论了它们的适应证和禁忌证，并探讨了它们是否可作为痤疮的一线治疗药物。
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