Service de Dermatologie, Pavillon Tarnier, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Faculté de Médecine, Université René Descartes - Paris V, 75014 Paris, France.
Clin Dermatol. 2010 Jan-Feb;28(1):45-51. doi: 10.1016/j.clindermatol.2009.03.009.
The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of atopic dermatitis.
探寻特应性皮炎（湿疹）的病理生理学机制已经持续了 25 个世纪。医生们渴望发现特应性皮炎的根本原因，以寻求治疗方法。近年来，科学研究揭示了越来越多相互作用的病理生理因素，包括表皮屏障、消化道菌群、食物、早期感染和抗原刺激，以及先天和适应性免疫反应；然而，过分关注其中的一些因素，以及对局部治疗的获益/风险平衡的误解，有时导致局部治疗被忽视。回顾病理生理学概念的历史，我们旨在将局部治疗重新置于特应性皮炎临床管理的中心。
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