Halling-Overgaard Anne-Sofie, Zachariae Claus, Thyssen Jacob P
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark.
Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark; National Allergy Research Centre, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup DK-2900, Denmark.
Dermatol Clin. 2017 Jul;35(3):365-372. doi: 10.1016/j.det.2017.02.010.
This article provides an overview of clinical aspects of hand eczema in patients with atopic dermatitis. Hand eczema can be a part of atopic dermatitis itself or a comorbidity, for example, as irritant or allergic contact dermatitis. When managing hand eczema, it is important to first categorize the subtype and identify potential culprit allergens or irritants. First-line therapy should be a combination of emollients and topical corticosteroids; possible alternatives include topical calcineurin inhibitors or coal tar. Second-line therapy includes UV therapy and systemic therapy, including azathioprine, cyclosporine, methotrexate, and mycophenolate. Prednisolone should only be very infrequently used.
本文概述了特应性皮炎患者手部湿疹的临床情况。手部湿疹可以是特应性皮炎本身的一部分，也可以是一种合并症，例如刺激性或过敏性接触性皮炎。在处理手部湿疹时，首先对亚型进行分类并识别潜在的致病过敏原或刺激物很重要。一线治疗应为润肤剂和外用皮质类固醇的联合使用；可能的替代方法包括外用钙调神经磷酸酶抑制剂或煤焦油。二线治疗包括紫外线疗法和全身治疗，包括硫唑嘌呤、环孢素、甲氨蝶呤和霉酚酸酯。泼尼松龙应极少使用。
