转化生长因子β3 多态性与高血压患者左心室结构的关系。

The association between transforming growth factor beta3 polymorphisms and left ventricular structure in hypertensive subjects.

机构信息

Zhejiang Provincial People's Hospital, Hangzhou, China.

出版信息

Clin Chim Acta. 2010 Apr 2;411(7-8):558-62. doi: 10.1016/j.cca.2010.01.014. Epub 2010 Jan 18.

DOI:10.1016/j.cca.2010.01.014

PMID:20083094

Abstract

BACKGROUND

Transforming growth factor beta (TGF-beta) may be a crucial regulator of cardiac remodeling. We investigated the association between the TGF-beta gene polymorphisms and left ventricular structure.

METHODS

A total of 658 hypertensive subjects were genotyped for the TGF-beta1 T869C and TGF-beta3 (rs3917187 and rs4252338) polymorphisms.

RESULTS

TGF-beta3 rs3917187 AA homozygotes had, while accounting for covariates, greater left ventricular end-systolic (LVESD, P=0.004) and end-diastolic dimension (LVEDD, P=0.007) than G allele carriers. Moreover, left ventricular mass index (LVMI) in AA genotype was 123.0+/-3.1g/m(2) significantly higher than that in AG (114.6+/-1.6g/m(2)) and GG (115.4+/-2.1g/m(2), P=0.03) genotypes. In multivariate regression analysis, TGF-beta3 rs3917187 genotype as an independent predictor had statistically significant effects on LVESD (beta=0.164, P=0.002), LVEDD (beta=0.172, P=0.003) and LVMI (beta=0.136, P=0.016), respectively. In further analyses, we observed a significant interaction between the rs3917187 and alcohol intake in relation to LVESD (P(int)=0.04) and left ventricular fractional shortening (LVFSH, P(int)=0.012). However, no relationship could be found between left ventricular parameters and the T869C or the rs4252338.

CONCLUSION

The present results demonstrated that the TGF-beta3 rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects.

摘要

背景

转化生长因子-β（TGF-β）可能是心脏重构的关键调节因子。我们研究了 TGF-β 基因多态性与左心室结构之间的关系。

方法

共对 658 例高血压患者进行 TGF-β1 T869C 和 TGF-β3（rs3917187 和 rs4252338）多态性基因分型。

结果

TGF-β3 rs3917187 AA 纯合子在考虑协变量后，左心室收缩末期（LVESD，P=0.004）和舒张末期（LVEDD，P=0.007）均大于 G 等位基因携带者。此外，AA 基因型的左心室质量指数（LVMI）为 123.0+/-3.1g/m(2)，显著高于 AG（114.6+/-1.6g/m(2)）和 GG（115.4+/-2.1g/m(2），P=0.03）基因型。在多元回归分析中，TGF-β3 rs3917187 基因型作为独立预测因子对 LVESD（β=0.164，P=0.002）、LVEDD（β=0.172，P=0.003）和 LVMI（β=0.136，P=0.016）具有统计学意义。在进一步的分析中，我们观察到 rs3917187 与饮酒之间存在显著的交互作用，与 LVESD（P(int)=0.04）和左心室缩短分数（LVFSH，P(int)=0.012）有关。然而，在高血压患者中，T869C 或 rs4252338 与左心室参数之间没有关系。