Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
J Hum Hypertens. 2012 Mar;26(3):171-7. doi: 10.1038/jhh.2011.8. Epub 2011 Feb 10.
Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C(-1306)T (rs243865) and C(-735)T (rs 2285053) MMP-2 polymorphisms were analysed. Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI). Multiple linear regression analysis was performed to assess whether MMP-2 genotypes or haplotypes affect LVMI and other echocardiography parameters. The C(-1306)T 'CC' genotype was associated with reduced LVMI and LV end-diastolic diameter (EDD) (P=0.0365 and P=0.0438, respectively). The haplotype 'C, C' was associated with reduced LVMI and EDD (P=0.0278 and P=0.0322, respectively). The comparison of upper and lower extremes of the LVMI phenotype showed that the 'C, C' haplotype was more common in the lower LVMI group (P=0.0060), whereas the 'T, C' haplotype was more common in the higher quartile of LVMI (P=0.0187), and this haplotype was associated with increased risk of higher LVMI values (odds ratio=3.5121, 95% confidence interval=1.3193-9.3494). The findings suggest that MMP-2 polymorphisms affect hypertension-induced LV remodelling.
基质金属蛋白酶（MMPs）参与心脏重构。我们研究了 MMP-2 基因多态性是否与高血压患者的高血压和左心室（LV）重构有关。我们研究了 160 名高血压患者和 123 名健康对照者。所有患者均进行超声心动图检查，并分析 MMP-2 的 C(-1306)T(rs243865)和 C(-735)T(rs2285053)多态性。使用 Haplo.stats 分析评估 MMP-2 单倍型是否与高血压以及 LV 质量指数（LVMI）极值有关。进行多元线性回归分析，以评估 MMP-2 基因型或单倍型是否影响 LVMI 和其他超声心动图参数。C(-1306)T'CC'基因型与 LVMI 和 LV 舒张末期直径（EDD）降低相关（P=0.0365 和 P=0.0438）。单倍型'C，C'与 LVMI 和 EDD 降低相关（P=0.0278 和 P=0.0322）。LVMI 表型上下极值的比较表明，'C，C'单倍型在 LVMI 较低的组中更为常见（P=0.0060），而'T，C'单倍型在 LVMI 较高的四分位数中更为常见（P=0.0187），并且该单倍型与较高的 LVMI 值相关（比值比=3.5121，95%置信区间=1.3193-9.3494）。研究结果表明，MMP-2 多态性影响高血压引起的 LV 重构。
