Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093-0322, USA.
FEBS Lett. 2010 Apr 2;584(7):1367-73. doi: 10.1016/j.febslet.2010.01.019. Epub 2010 Jan 17.
Pexophagy is a selective autophagy process wherein damaged and/or superfluous peroxisomes undergo vacuolar degradation. In methylotropic yeasts, where pexophagy has been studied most extensively, this process occurs by either micro- or macropexophagy: processes analogous to micro- and macroautophagy. Recent studies have identified specific factors and illustrated mechanisms involved in pexophagy. Although mechanistically pexophagy relies heavily on the core autophagic machinery, the latest findings about the role of auxiliary pexophagy factors have highlighted specialized membrane structures required for micropexophagy, and shown how cargo selectivity is achieved and how cargo size dictates the requirement for these factors during pexophagy. These insights and additional observations in the literature provide a framework for an understanding of the physiological role(s) of pexophagy.
pexophagy 是一种选择性自噬过程，在此过程中受损和/或多余的过氧化物酶体经历液泡降解。在甲醇营养型酵母中，pexophagy 研究最为广泛，这个过程通过微噬或巨噬发生：类似于微自噬和巨自噬的过程。最近的研究已经确定了参与 pexophagy 的特定因素和机制。尽管在机制上，pexophagy 严重依赖于核心自噬机制，但最近关于辅助 pexophagy 因子作用的发现强调了微噬所需的专门膜结构，并展示了如何实现货物选择性以及货物大小如何决定这些因子在 pexophagy 过程中的需求。这些见解和文献中的其他观察结果为理解 pexophagy 的生理作用提供了一个框架。
