Department of Pathology, Huntingdon Life Sciences, Woolley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, UK.
Toxicol Lett. 2010 Mar 15;193(2):179-82. doi: 10.1016/j.toxlet.2010.01.005. Epub 2010 Jan 18.
Pancreas of Beagle dogs deriving from 166 male and 166 female animals were examined microscopically and were found to show nesidioblastosis-like structural alteration in 29 dogs. The lesion was represented by endocrine and ductular epithelial cell proliferation. The incidence profile and the severity of the changes observed were closely associated with the age of the dogs, younger dogs being more often and more seriously affected than older dogs. No link with altered insulin function has been established as serum glucose levels were found to be within the normal range. The pathology of spontaneous extra-islet endocrine cell proliferation in the young Beagle dogs, described in this study, has some similarities to that of nesidioblastosis of human neonates and infants.
从 166 只雄性和 166 只雌性比格犬中取出的胰腺进行了显微镜检查，发现 29 只犬存在类 nesidioblastosis 的结构改变。病变表现为内分泌和导管上皮细胞增生。观察到的病变发生率和严重程度与犬的年龄密切相关，年龄较小的犬比年龄较大的犬更常且更严重地受到影响。由于血清葡萄糖水平在正常范围内，因此未发现与胰岛素功能改变有关。本研究中描述的年轻比格犬胰岛外内分泌细胞增殖的病理学与新生儿和婴儿的 nesidioblastosis 有一些相似之处。
