Overturf G D, Powars D R, McAllister R M, Pegelow C, Charman H P
Med Pediatr Oncol. 1977;3(4):345-50. doi: 10.1002/mpo.2950030404.
A 5-year-old child developed acute lymphoblastic leukemia during convalescence from an episode of Reye's syndrome that was treated with multiple exchange transfusions. Routine laboratory, histology, and viral serology were unable to establish a common etiology for the 2 illnesses. Cultural and immunologic methods to search for evidence of infection with type-C viruses or viral genes in lymphoblasts from the buffy coat and bone marrow failed to reveal these agents. Although no common infectious etiology was defined for the close temporal occurrence of 2 rare diseases, the possibility of an iatrogenically induced malignancy was considered.
一名5岁儿童在瑞氏综合征恢复期发生急性淋巴细胞白血病，该患儿曾接受多次换血治疗。常规实验室检查、组织学检查及病毒血清学检查均无法确定这两种疾病的共同病因。采用培养和免疫学方法在血沉棕黄层及骨髓的淋巴母细胞中寻找C型病毒感染证据或病毒基因，但未发现这些病原体。尽管未能确定这两种罕见疾病在时间上紧密关联的共同感染病因，但考虑了医源性诱发恶性肿瘤的可能性。
