Dias da Silva Wilmar, Tambourgi Denise V
Immunochemistry Laboratory, Butantan Institute, Av. Vital Brazil 1500, 05503-900 São Paulo, Brazil.
Vet Immunol Immunopathol. 2010 Jun 15;135(3-4):173-80. doi: 10.1016/j.vetimm.2009.12.011. Epub 2010 Jan 7.
Immunoglobulin IgY is the major antibody produced by chickens (Gallus domesticus). After their V-C gene is rearranged in B cells, IgY is continually synthesized, excreted into the blood and transferred to the egg yolk, where it is accumulated. IgY is produced by hens to provide their offspring with an effective humoral immunity against the commonest avian pathogens until full maturation of their own immune system. In this review we aim to give an overview about the generation, structure, properties of IgY, as well as the advantages of chicken antibodies use over mammalian antibodies in immunodiagnostics and immunotherapy.
免疫球蛋白IgY是鸡（家鸡）产生的主要抗体。其V-C基因在B细胞中重排后，IgY持续合成，分泌到血液中并转移至蛋黄中积累。母鸡产生IgY是为了在其后代自身免疫系统完全成熟之前，为它们提供针对最常见禽类病原体的有效体液免疫。在本综述中，我们旨在概述IgY的产生、结构、特性，以及在免疫诊断和免疫治疗中使用鸡抗体相对于哺乳动物抗体的优势。
