Sleep Disorders Unit, Department of Thoracic Medicine, Medical School, University of Crete, Heraklion, Voutes, P.O. 71110, Greece.
Sleep Med. 2010 Feb;11(2):149-53. doi: 10.1016/j.sleep.2009.07.016. Epub 2010 Jan 18.
Little is known about sleep quality in patients with acute coronary syndromes (ACS) admitted to the coronary care unit (CCU). The aim of this study was to assess nocturnal sleep in these patients, away from the CCU environment, and to evaluate potential connections with the disease process.
Twenty-two patients with first ever ACS, who were not on sedation or inotropes, underwent a full-night polysomnography (PSG) in our sleep disorders unit within 3 days of the ACS and follow-up PSGs 1 and 6 months later.
PSG parameters showed a progressive improvement over the study period. There was a statistically significant increase in total sleep time (TST), sleep efficiency, slow wave sleep (SWS), and rapid eye movement (REM) sleep, while arousal index, wake after sleep onset (WASO) and sleep latency decreased. Six months after the acute event, sleep architecture was within the normal range.
Patients with ACS have marked alterations in sleep macro- and micro-architecture, which have a negative influence on sleep quality. The changes tend to disappear over time, suggesting a relationship with the acute phase of the underlying disease.
对于入住冠心病监护病房（CCU）的急性冠状动脉综合征（ACS）患者的睡眠质量，我们知之甚少。本研究旨在评估这些患者离开 CCU 环境后的夜间睡眠，并评估与疾病进程的潜在联系。
22 名首次 ACS 患者，在 ACS 发生后 3 天内在我们的睡眠障碍病房接受了一整夜的多导睡眠图（PSG）检查，并在 1 个月和 6 个月后进行了随访 PSG。
PSG 参数在研究期间呈逐渐改善。总睡眠时间（TST）、睡眠效率、慢波睡眠（SWS）和快速眼动（REM）睡眠均有统计学意义的增加，而觉醒指数、睡眠后觉醒（WASO）和睡眠潜伏期则减少。急性事件发生 6 个月后，睡眠结构恢复正常范围。
ACS 患者的睡眠宏观和微观结构发生了明显改变，这对睡眠质量有负面影响。这些变化随着时间的推移而消失，提示与潜在疾病的急性期有关。
