药物难治性癫痫患者的首夜效应及睡眠参数分析

Analysis of the first night effect and sleep parameters in medically refractory epilepsy patients.

作者信息

Marzec Mary L, Selwa Linda M, Malow Beth A

机构信息

Michael S. Aldrich Sleep Disorders Center, Department of Neurology, University of Michigan Medical Center, 1500 E. Medical Center Dr., Rm. 8D-8702 Ann Arbor, MI 48109-0117, USA.

出版信息

Sleep Med. 2005 May;6(3):277-80. doi: 10.1016/j.sleep.2005.01.002.

DOI:10.1016/j.sleep.2005.01.002

PMID:15854859

Abstract

OBJECTIVES

To assess the first night effect (FNE) and compare sleep stage proportions to normative values in a sample of medically refractory epilepsy patients.

PATIENTS AND METHODS

Sleep parameters of 53 epilepsy patients, ages (18-56, mean: 34+/-12, 25 females 28 men), who underwent two consecutive nights of polysomnography (PSG) were compared. Non-rapid eye movement (NREM) stage 3 and NREM stage 4 were combined as slow wave sleep (SWS). Sleep efficiency, sleep latency, rapid eye movement (REM) latency, number of stage shifts, total minutes and proportion of total sleep time for stage 1, stage 2, SWS, and REM sleep were compared between the 2 nights.

RESULTS

SWS was the only parameter that differed between nights 1 and 2 for both total minutes (P=0.02) and proportion of total sleep time (P=0.01), although the means for both nights were within the normative range. Comparing sleep proportions to normative values indicates that our patients had increased NREM stage 1 and decreased REM sleep.

CONCLUSIONS

We observed a minimal FNE in this sample of epilepsy patients manifested by reduced SWS. Multiple PSGs to accommodate the FNE may not be necessary in this population.

摘要

目的

评估难治性癫痫患者样本中的首夜效应（FNE），并将睡眠阶段比例与正常数值进行比较。

患者与方法

对53例癫痫患者（年龄18 - 56岁，平均34±12岁，女性25例，男性28例）连续两晚进行多导睡眠图（PSG）监测，比较其睡眠参数。非快速眼动（NREM）3期和NREM 4期合并为慢波睡眠（SWS）。比较两晚之间的睡眠效率、入睡潜伏期、快速眼动（REM）潜伏期、睡眠阶段转换次数、第1阶段、第2阶段、SWS和REM睡眠的总分钟数及占总睡眠时间的比例。