Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK.
Trends Parasitol. 2010 Mar;26(3):103-6. doi: 10.1016/j.pt.2009.12.006. Epub 2010 Jan 18.
The blood flukes Schistosoma japonicum and Schistosoma mansoni are the first major human platyhelminth pathogens to have their genome sequences published. The work of two large international consortia offers draft sequence information and detailed analyses presenting a wealth of information addressing, in particular, metabolic and signalling pathways, host-parasite interactions and potential new drug targets. We comment on these breakthroughs and their potential applications in the study and control of schistosomes.
日本血吸虫和曼氏血吸虫是首批被公布其基因组序列的大型人体扁形动物病原体。两个大型国际研究团队的工作提供了草案序列信息和详细分析，这些信息特别针对代谢和信号通路、宿主-寄生虫相互作用以及潜在的新药物靶点，提供了丰富的信息。我们对这些突破及其在血吸虫研究和控制中的潜在应用进行了评论。
