Hokke Cornelis H, Fitzpatrick Jennifer M, Hoffmann Karl F
Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Trends Parasitol. 2007 Apr;23(4):165-74. doi: 10.1016/j.pt.2007.02.007. Epub 2007 Mar 1.
Publication of the transcriptomes of Schistosoma mansoni and Schistosoma japonicum, in conjunction with the sequencing and assembly of their genomes, has generated a comprehensive picture of Schistosoma transcriptional and genomic diversity. Subsequently, researchers who study conjugal and developmental biology, tegumental composition and larval or egg, secretory and excretory products have used these data, in combination with the latest '-omics' technologies, to extend large-scale screens of the schistosome transcriptome, proteome and glycome. In this article, we review these postgenomic investigations and contend that the generated datasets provide a plethora of novel drug, vaccine and immunomodulatory targets that might be useful for developing new antischistosome agents.
曼氏血吸虫和日本血吸虫转录组的发表，连同其基因组的测序和组装，形成了一幅关于血吸虫转录和基因组多样性的全面图景。随后，研究交配与发育生物学、体表组成以及幼虫或虫卵、分泌和排泄产物的研究人员，结合最新的“组学”技术，利用这些数据扩展了对血吸虫转录组、蛋白质组和糖组的大规模筛选。在本文中，我们回顾了这些后基因组研究，并认为所生成的数据集提供了大量新的药物、疫苗和免疫调节靶点，这些靶点可能有助于开发新的抗血吸虫药物。
