Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany.
Hypertension. 2010 Mar;55(3):593-9. doi: 10.1161/HYPERTENSIONAHA.109.134213. Epub 2010 Jan 18.
Atherosclerosis is the most common cause for cardiovascular diseases and is based on endothelial dysfunction. A growing body of evidence suggests the contribution of bone marrow-derived endothelial progenitor cells, monocytic cells, and mature endothelial cells to vessel formation and endothelial rejuvenation. To this day, various subsets of these endothelial-regenerating cells have been identified according to cellular origin, phenotype, and properties in vivo and in vitro. However, the definition and biology, especially of endothelial progenitor cells, is complex and under heavy debate. In this review, we focus on current definitions of endothelial progenitor cells, highlight the clinical relevance of endothelial-regenerating cells, and provide new insights into cell-cell interactions involved in endothelial cell rejuvenation.
动脉粥样硬化是心血管疾病最常见的病因，其基础是内皮功能障碍。越来越多的证据表明，骨髓来源的内皮祖细胞、单核细胞和成熟内皮细胞对血管形成和内皮细胞再生有贡献。时至今日，根据细胞起源、表型和体内、体外特性，已经鉴定出这些具有内皮再生能力的细胞的各种亚群。然而，内皮祖细胞的定义和生物学特性非常复杂，存在激烈的争论。在这篇综述中，我们关注内皮祖细胞的当前定义，强调内皮再生细胞的临床相关性，并提供关于参与内皮细胞再生的细胞-细胞相互作用的新见解。
