The Vitreous, Retina, Macula Consultants of New York, New York, New York 10022, USA.
Retina. 2010 Apr;30(4):542-7. doi: 10.1097/IAE.0b013e3181c713e4.
The purpose of this study was to describe intraretinal crystalline deposits detected in eyes with neovascular age-related macular degeneration.
A retrospective review of patients seen during a 6-month period with the diagnosis of neovascular age-related macular degeneration was performed to identify patients with intraretinal crystalline deposits, defined as pinpoint refractile bodies within the neurosensory retina. The characteristics of the deposits, including their shape, size, distribution, and location within the retina, were determined by analyzing color and red-free fundus photographs and spectral domain-optical coherence tomography images.
Fourteen eyes of 13 patients with neovascular age-related macular degeneration manifesting intraretinal crystalline deposits were identified. The patients had no history of ocular or systemic disease or prior medication use known to be associated with intraretinal crystals. Intravitreal antivascular endothelial growth factor injection was used in 10 eyes, laser photocoagulation in 3 eyes, and intravitreal triamcinolone in 1 eye. The retinal crystals were detected in the macula overlying or adjacent to the areas of choroidal neovascularization. The crystalline deposits could be localized with spectral domain-optical coherence tomography to both the outer nuclear and the outer plexiform layers.
Intraretinal crystalline deposits localized to the outer nuclear and outer plexiform layers can be detected in eyes with a history of neovascular age-related macular degeneration, often after treatment with a variety of different modalities. Potential etiologies of these deposits include residual lipid material from choroidal neovascularization leakage, degenerated Müller cell elements, and because these deposits were found in eyes with assorted forms of treatment, an external factor such as diet may play a role.
本研究旨在描述新生血管性年龄相关性黄斑变性患者眼中的视网膜内结晶沉积物。
对 6 个月内诊断为新生血管性年龄相关性黄斑变性的患者进行回顾性研究，以确定存在视网膜内结晶沉积物的患者，定义为神经感觉视网膜内的针尖状折射体。通过分析彩色和无红色眼底照片和光谱域光相干断层扫描图像来确定沉积物的特征，包括其形状、大小、分布和在视网膜内的位置。
确定了 13 例患有新生血管性年龄相关性黄斑变性且表现出视网膜内结晶沉积物的患者的 14 只眼。这些患者没有眼部或全身疾病史，也没有使用已知与视网膜内晶体有关的药物。10 只眼接受了玻璃体内抗血管内皮生长因子注射，3 只眼接受了激光光凝，1 只眼接受了玻璃体内曲安奈德注射。视网膜晶体位于脉络膜新生血管上方或附近的黄斑区。结晶沉积物可以通过光谱域光相干断层扫描定位在外核和外丛状层。
在有新生血管性年龄相关性黄斑变性病史的眼中，可以检测到定位于外核和外丛状层的视网膜内结晶沉积物，这些沉积物通常在接受各种不同治疗方式后出现。这些沉积物的潜在病因包括脉络膜新生血管渗漏的残余脂质物质、变性的 Müller 细胞成分，由于这些沉积物出现在各种治疗方式的眼中，饮食等外部因素可能起作用。
