Department of Ophthalmology, Gunma University School of Medicine, 3-39-15 Showa-Machi, Maebashi, Gunma 371-8511, Japan.
Retina. 2010 Mar;30(3):425-30. doi: 10.1097/IAE.0b013e3181bd2d95.
The purpose of this study was to define the origin of intraretinal neovascularization in retinal angiomatous proliferation with spectral domain-optical coherence tomography.
We retrospectively studied nine consecutive eyes of seven patients (two eyes of two men, seven eyes of five women) with untreated retinal angiomatous proliferation using fluorescein and indocyanine green angiography and spectral domain-optical coherence tomography. One eye had stage I disease, two eyes had stage II disease with no pigment epithelial detachment, and six eyes had stage II disease with pigment epithelial detachment. We evaluated the location of the intraretinal neovascularization, disruption of the retinal pigment epithelium, retinal edema, and serous retinal detachments.
Intraretinal neovascularization appeared as a highly reflective mass from the outer plexiform layer to the deeper layer in seven eyes. The underlying retinal pigment epithelium was disrupted beneath the intraretinal neovascularization in all eyes. All eyes had retinal edema around the intraretinal neovascularization. Serous retinal detachments were seen in only two eyes with stage II disease with pigment epithelial detachment. Intraretinal neovascularization originated outside the foveal avascular zone in all eyes.
Intraretinal neovascularization seems to originate from the deep retinal capillaries at the outer plexiform layer and grow toward the retinal pigment epithelium.
本研究旨在通过频域光相干断层扫描来确定视网膜血管瘤样增生中视网膜内新生血管的起源。
我们回顾性研究了 7 名患者（2 名男性，2 名女性）9 只未经治疗的视网膜血管瘤样增生眼的荧光素和吲哚青绿血管造影及频域光相干断层扫描检查结果。其中 1 只眼为 1 期病变，2 只眼为无色素上皮脱离的 2 期病变，6 只眼为合并色素上皮脱离的 2 期病变。我们评估了视网膜内新生血管的位置、视网膜色素上皮的破坏、视网膜水肿和浆液性视网膜脱离。
7 只眼中，视网膜内新生血管呈高反射团，从外丛状层到深层。所有眼的视网膜下新生血管下方的视网膜色素上皮均有破坏。所有眼的视网膜内新生血管周围均有视网膜水肿。仅 2 只合并色素上皮脱离的 2 期病变眼有浆液性视网膜脱离。所有眼的视网膜内新生血管均起源于黄斑无血管区以外。
视网膜内新生血管似乎起源于外丛状层的深层视网膜毛细血管，并向视网膜色素上皮生长。
