NLRP3喜欢甜食。 - Suppr

NLRP3 has a sweet tooth.

作者信息

Davis Beckley K, Ting Jenny Pan-Yun

机构信息

Department of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

出版信息

Nat Immunol. 2010 Feb;11(2):105-6. doi: 10.1038/ni0210-105.

DOI:10.1038/ni0210-105

PMID:20084064

Abstract

摘要

相似文献

NLRP3 has a sweet tooth.NLRP3喜欢甜食。

Nat Immunol. 2010 Feb;11(2):105-6. doi: 10.1038/ni0210-105.

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?NLRP3 炎性小体激活：ROS 产生的多种信号通路汇聚？

Nat Rev Immunol. 2010 Mar;10(3):210-5. doi: 10.1038/nri2725. Epub 2010 Feb 19.

The NLRP3 inflammasome: a sensor for metabolic danger?NLRP3 炎性体：代谢危险的传感器？

Science. 2010 Jan 15;327(5963):296-300. doi: 10.1126/science.1184003.

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome.紫薯花色苷通过阻断 NLRP3 炎性小体抑制内皮细胞过早衰老。

J Nutr Biochem. 2015 Oct;26(10):1029-40. doi: 10.1016/j.jnutbio.2015.04.012. Epub 2015 May 15.

Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production.环氧化酶-2 调节 NLRP3 炎性体衍生的白细胞介素-1β产生。

J Cell Physiol. 2015 Apr;230(4):863-74. doi: 10.1002/jcp.24815.

Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients.活性氧激活NLRP3炎性小体，在高渗应激的人角膜上皮细胞和环境诱导的干眼患者中引发炎症。

Exp Eye Res. 2015 May;134:133-40. doi: 10.1016/j.exer.2015.02.013. Epub 2015 Feb 18.

Thioredoxin-interacting protein links oxidative stress to inflammasome activation.硫氧还蛋白相互作用蛋白将氧化应激与炎症小体激活联系起来。

Nat Immunol. 2010 Feb;11(2):136-40. doi: 10.1038/ni.1831. Epub 2009 Dec 20.

Coronary endothelial dysfunction induced by nucleotide oligomerization domain-like receptor protein with pyrin domain containing 3 inflammasome activation during hypercholesterolemia: beyond inflammation.高胆固醇血症期间含3个吡啉结构域的核苷酸寡聚化结构域样受体蛋白炎性小体激活诱导的冠状动脉内皮功能障碍：超越炎症反应

Antioxid Redox Signal. 2015 May 1;22(13):1084-96. doi: 10.1089/ars.2014.5978. Epub 2015 Mar 31.

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.活性氧激活 NLRP3 炎性体引发环境诱导的小鼠干眼。

Exp Eye Res. 2014 Aug;125:1-8. doi: 10.1016/j.exer.2014.05.001. Epub 2014 May 14.

Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes.脂质环境可诱导 2 型糖尿病患者免疫细胞内质网应激、TXNIP 表达和炎症反应。

Diabetologia. 2018 Feb;61(2):399-412. doi: 10.1007/s00125-017-4462-5. Epub 2017 Oct 7.

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PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages.PARP-1 通过 NLRP3 的聚 ADP-核糖化和与原代巨噬细胞中 TXNIP 的相互作用来调节炎症小体的活性。

Cell Mol Life Sci. 2022 Jan 30;79(2):108. doi: 10.1007/s00018-022-04138-z.

The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target.TXNIP 在缺血性和心血管疾病中的新作用；一种新的标志物和治疗靶点。

Int J Mol Sci. 2021 Feb 8;22(4):1693. doi: 10.3390/ijms22041693.

Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response .造血细胞激酶（HCK）对NLRP3炎性小体激活和脂多糖诱导的炎症反应至关重要。

Front Pharmacol. 2020 Sep 15;11:581011. doi: 10.3389/fphar.2020.581011. eCollection 2020.

Honokiol antagonizes doxorubicin‑induced cardiomyocyte senescence by inhibiting TXNIP‑mediated NLRP3 inflammasome activation.和厚朴酚通过抑制 TXNIP 介导的 NLRP3 炎性小体激活拮抗阿霉素诱导的心肌细胞衰老。

Int J Mol Med. 2020 Jan;45(1):186-194. doi: 10.3892/ijmm.2019.4393. Epub 2019 Nov 1.

Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells.网状应激和未折叠蛋白反应对子宫内膜基质细胞炎症反应的影响。

Sci Rep. 2018 Aug 16;8(1):12274. doi: 10.1038/s41598-018-29779-8.

Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis.NADPH氧化酶在双糖链蛋白聚糖触发的白细胞介素-1β合成调节中的双峰作用。

Matrix Biol. 2016 Jan;49:61-81. doi: 10.1016/j.matbio.2015.12.005. Epub 2015 Dec 12.

IL-1β and IL-18: inflammatory markers or mediators of hypertension?白细胞介素-1β和白细胞介素-18：高血压的炎症标志物还是介质？

Br J Pharmacol. 2014 Dec;171(24):5589-602. doi: 10.1111/bph.12876.

TXNIP shuttling: missing link between oxidative stress and inflammasome activation.硫氧还蛋白相互作用蛋白穿梭：氧化应激与炎性小体激活之间缺失的环节

Front Physiol. 2013 Mar 21;4:50. doi: 10.3389/fphys.2013.00050. eCollection 2013.

NLRP3 inflammasome activation induced by engineered nanomaterials.工程纳米材料诱导的 NLRP3 炎性小体激活。

Small. 2013 May 27;9(9-10):1595-607. doi: 10.1002/smll.201201962. Epub 2012 Nov 23.

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.广泛的固有免疫基因激活伴随着大脑衰老，增加了认知能力下降和神经退行性变的易感性：一项微阵列研究。

J Neuroinflammation. 2012 Jul 23;9:179. doi: 10.1186/1742-2094-9-179.

本文引用的文献

Thioredoxin-interacting protein links oxidative stress to inflammasome activation.硫氧还蛋白相互作用蛋白将氧化应激与炎症小体激活联系起来。

Nat Immunol. 2010 Feb;11(2):136-40. doi: 10.1038/ni.1831. Epub 2009 Dec 20.

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.格列本脲抑制冷吡啉/Nalp3炎性小体。

J Cell Biol. 2009 Oct 5;187(1):61-70. doi: 10.1083/jcb.200903124.

Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response.病原体诱导的白细胞介素-1β加工和分泌受双相氧化还原反应调控。

J Immunol. 2009 Jul 15;183(2):1456-62. doi: 10.4049/jimmunol.0900578. Epub 2009 Jun 26.

The inflammasomes: guardians of the body.炎性小体：身体的守护者。

Annu Rev Immunol. 2009;27:229-65. doi: 10.1146/annurev.immunol.021908.132715.

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.二氧化硅晶体和铝盐通过吞噬体不稳定激活NALP3炎性小体。

Nat Immunol. 2008 Aug;9(8):847-56. doi: 10.1038/ni.1631. Epub 2008 Jul 11.

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.超氧化物歧化酶1调节半胱天冬酶-1和内毒素休克。

Nat Immunol. 2008 Aug;9(8):866-72. doi: 10.1038/ni.1633. Epub 2008 Jul 6.

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.通过Nalp3炎性小体感知石棉和二氧化硅激活先天免疫。

Science. 2008 May 2;320(5876):674-7. doi: 10.1126/science.1156995. Epub 2008 Apr 10.

NLRX1 is a regulator of mitochondrial antiviral immunity.NLRX1是线粒体抗病毒免疫的调节因子。

Nature. 2008 Jan 31;451(7178):573-7. doi: 10.1038/nature06501. Epub 2008 Jan 16.

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.由炎性小体成分CIAS1/冷吡啉/NLRP3和ASC介导的微生物病原体诱导的坏死性细胞死亡。

Cell Host Microbe. 2007 Sep 13;2(3):147-59. doi: 10.1016/j.chom.2007.07.009.

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation.焦亡小体：一种由ASC二聚体组成的超分子组装体，通过半胱天冬酶-1激活介导炎症性细胞死亡。

Cell Death Differ. 2007 Sep;14(9):1590-604. doi: 10.1038/sj.cdd.4402194. Epub 2007 Jun 29.

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NLRP3 has a sweet tooth.

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