INSERM 1140, Innovative Therapies in Haemostasis, Faculty of Pharmacy, Université de Paris, 75006 Paris, France.
Clinical Biochemistry Department, Assistance Publique des Hôpitaux de Paris, Necker Hospital, 75015 Paris, France.
Int J Mol Sci. 2021 Feb 8;22(4):1693. doi: 10.3390/ijms22041693.
Thioredoxin interacting protein (TXNIP) is a metabolism- oxidative- and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases.
硫氧还蛋白相互作用蛋白（TXNIP）是一种在心血管疾病中诱导的代谢-氧化和炎症相关标志物，被认为代表了代谢和细胞氧化还原状态之间的可能联系。TXNIP 是心血管和缺血性疾病的潜在生物标志物，但也是预防和治疗医学的新确定靶点。本综述的目的是重点关注 TXNIP 的新进展。在概述了 TXNIP 在氧化应激、炎症和代谢中的作用后，本综述的其余部分介绍了在心血管和缺血性疾病中，将 TXNIP 定义为遗传、血液或缺血部位水平上新标志物的线索。
