效应因子和记忆：Bcl-6 和 Blimp-1 在 T 和 B 淋巴细胞分化中的作用。
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation.
机构信息
Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
出版信息
Nat Immunol. 2010 Feb;11(2):114-20. doi: 10.1038/ni.1837. Epub 2010 Jan 19.
Abstract
Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of effector and memory differentiation in CD4(+) T cells and CD8(+) T cells. Bcl-6 and Blimp-1 were previously known to be critical regulators of effector and memory differentiation of B lymphocytes. The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. Bcl-6 and Blimp-1 are antagonistic transcription factors and can function as a self-reinforcing genetic switch for cell-fate decisions. However, their influences in different lymphocytes are complex. Here we review and examine the commonalities and differences in the functions of these transcription factors in CD4(+) follicular helper T(FH) lymphocytes, effector CD8(+) T lymphocytes and B lymphocytes.
摘要
Bcl-6 和 Blimp-1 最近被确定为 CD4(+) T 细胞和 CD8(+) T 细胞效应器和记忆分化的关键转录调节因子。Bcl-6 和 Blimp-1 以前被认为是 B 淋巴细胞效应器和记忆分化的关键调节因子。新发现出人意料地指出 Bcl-6 和 Blimp-1 调节轴是控制效应器和记忆淋巴细胞分化和功能的普遍机制。Bcl-6 和 Blimp-1 是拮抗转录因子，可作为细胞命运决定的自我强化遗传开关。然而，它们在不同淋巴细胞中的影响是复杂的。在这里，我们回顾并检查了这些转录因子在 CD4(+) 滤泡辅助 T(FH) 淋巴细胞、效应 CD8(+) T 淋巴细胞和 B 淋巴细胞中的功能的异同。
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