Bcl6介导滤泡辅助性T细胞的发育。
Bcl6 mediates the development of T follicular helper cells.
作者信息
Nurieva Roza I, Chung Yeonseok, Martinez Gustavo J, Yang Xuexian O, Tanaka Shinya, Matskevitch Tatyana D, Wang Yi-Hong, Dong Chen
机构信息
Department of Immunology, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Science. 2009 Aug 21;325(5943):1001-5. doi: 10.1126/science.1176676. Epub 2009 Jul 23.
Abstract
A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation.
摘要
CD4⁺辅助性T（T(H)）细胞的一项基本功能是调节B细胞介导的体液免疫。为B细胞提供辅助的滤泡辅助性T（T(FH)）细胞的发育由细胞因子白细胞介素-6和白细胞介素-21介导，但独立于TH1、TH2和TH17效应细胞谱系。在此，我们阐述了在T(FH)细胞中选择性表达的转录因子Bcl6的功能。Bcl6的表达受白细胞介素-6和白细胞介素-21调控。Bcl6的过表达以DNA结合依赖的方式诱导T(FH)相关基因表达并抑制其他T(H)谱系细胞分化。此外，T细胞中Bcl6的缺陷导致T(FH)细胞发育和生发中心反应受损，并改变了其他效应T细胞亚群的产生。因此，我们的数据表明Bcl6是T(FH)细胞生成编程所必需的。
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