Prentice R L
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Prev Med. 1991 Jan;20(1):147-57. doi: 10.1016/0091-7435(91)90015-v.
Cancer prevention trials are contrasted with cancer therapy trials, cardiovascular disease prevention trials, epidemiologic cohort and case-control studies, and trials with surrogate endpoints, in order to highlight some of their unique features and in order to examine the role of such trials in the cancer prevention agenda. The implication of these features and this role are discussed with respect to trial rationale, trial design, and trial protocol, with planning exercises for proposed dietary fat intervention trials among women providing illustration. Finally, some considerations are mentioned for the planning of a primary prevention trial of breast cancer using tamoxifen.
癌症预防试验与癌症治疗试验、心血管疾病预防试验、流行病学队列研究和病例对照研究以及替代终点试验形成对比，以突出其一些独特特征，并审视此类试验在癌症预防议程中的作用。将从试验原理、试验设计和试验方案方面讨论这些特征和作用的影响，并以针对女性的拟议膳食脂肪干预试验的规划实例加以说明。最后，提及了使用他莫昔芬进行乳腺癌一级预防试验规划时的一些注意事项。
