Faculdade de Medicina de Botucatu, UNESP, Botucatu, SP, Brasil.
Arq Bras Cardiol. 2009 Nov;93(5):526-33. doi: 10.1590/s0066-782x2009001100014.
Although a high fat diet (HFD) promotes nutritional and heart disorders, few studies have assessed its influence in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR).
To evaluate and compare the nutritional and cardiovascular profiles of WKY and SHR on a high fat diet.
20 WKY and 20 SHR were divided into four groups: Control-WKY (C-WKY), HFD-WKY, Control-SHR (C-SHR) and HFD-SHR. The C and HFD groups received, respectively, a normocaloric diet and a HFD for 20 weeks. The following features were evaluated: body weight (BW), adiposity, blood glucose, serum lipids, with measurements of total cholesterol and triacylglycerol levels, insulin and leptin. The cardiovascular study included the systolic blood pressure (SBP), a cardiopulmonary anatomical evaluation, an echocardiography and heart histology.
The SHR had BW, adiposity, glucose, cholesterol, triacylglycerol, leptin and insulin levels lower than the WKY. In SHR, the caloric intake increased with HFD. In WKY, the HFD increased energy efficiency, adiposity and blood leptin, and reduced glucose. In the cardiovascular assessment, the SHR had SBP, pulmonary moisture, myocardial hypertrophy and interstitial fibrosis higher than the WKY (p <0.01); the cardiac function was similar in both strains. The HFD reduced the ventricular systolic diameter in the WKY and increased the mitral E/A ratio, the diastolic thickness of the interventricular septum and the posterior wall, as well as the interstitial fibrosis of the left ventricle. (Arq Bras Cardiol 2009; 93(5) : 487-494)
Although it had not significantly affected the nutritional profile of the SHR, the treatment increased cardiac remodeling and precipitated the emergence of ventricular diastolic dysfunction. In WKY, the diet increased adiposity and leptinemia, and promoted non-significant cardiovascular changes.
尽管高脂肪饮食（HFD）会促进营养和心脏紊乱，但很少有研究评估其对正常血压的 Wistar-Kyoto 大鼠（WKY）和自发性高血压大鼠（SHR）的影响。
评估和比较高脂肪饮食对 WKY 和 SHR 的营养和心血管特征的影响。
将 20 只 WKY 和 20 只 SHR 分为四组：对照-WKY（C-WKY）、高脂肪饮食-WKY（HFD-WKY）、对照-SHR（C-SHR）和高脂肪饮食-SHR（HFD-SHR）。C 和 HFD 组分别接受正常热量饮食和高脂肪饮食 20 周。评估以下特征：体重（BW）、肥胖、血糖、血清脂质，包括总胆固醇和三酰甘油水平、胰岛素和瘦素。心血管研究包括收缩压（SBP）、心肺解剖评估、超声心动图和心脏组织学。
SHR 的 BW、肥胖、葡萄糖、胆固醇、三酰甘油、瘦素和胰岛素水平低于 WKY。在 SHR 中，高热量饮食增加了热量摄入。在 WKY 中，HFD 增加了能量效率、肥胖和血液瘦素，并降低了血糖。在心血管评估中，SHR 的 SBP、肺湿度、心肌肥大和间质纤维化高于 WKY（p<0.01）；两种菌株的心脏功能相似。HFD 降低了 WKY 的心室收缩直径，并增加了二尖瓣 E/A 比值、室间隔和后壁的舒张厚度以及左心室间质纤维化。
尽管它对 SHR 的营养状况没有显著影响，但这种治疗增加了心脏重构并促使出现心室舒张功能障碍。在 WKY 中，饮食增加了肥胖和瘦素血症，并促进了非显著的心血管变化。
