Division of Operating Theatre, Tottori University Hospital, Tottori, Japan.
J Anesth. 2010 Apr;24(2):192-6. doi: 10.1007/s00540-009-0840-6. Epub 2010 Jan 19.
We conducted a randomized, double-blinded study to test our hypothesis that caudal blockade as preemptive analgesia for low back surgery might accelerate time to walking exercise following surgery and reduce postoperative analgesics, thereby attaining faster recovery of cognitive function.
Our study included 51 elderly patients >70 years with American Society of Anesthesiologists (ASA) physical status 1-3, who underwent lumbosacral surgery under general anesthesia. After anesthetic induction and tracheal intubation, patients in the study group (group B) were injected with simple 0.5% bupivacaine [10 ml x height (m)] as a caudal block 15 min before surgical incision, whereas patients in the control group (group C) received normal saline. After surgery, patients had access to intravenous patient-administered analgesia (IV PCA), fentanyl, for postoperative pain relief. We assessed Mini-Mental State Examination (MMSE) scores before and after the surgery, values of visual analog scale (VAS) for postoperative analgesic status, fentanyl consumption during and for 3 days after surgery, and time to begin walking exercise after surgery.
VAS value of group B patients was significantly lower than those in group C throughout the postoperative 48-h period (p < 0.005), and group B patients began walking exercise significantly earlier than those in group C [mean +/- standard deviation (SD) 70.2 (14.3) in group C, and 61.9 (7.6) in group B; p = 0.0133]. Cognitive function level was higher in group B than in group C patients 24 h after operation.
Caudal blockade as preemptive analgesia shortened the time to start walking exercise after surgery and accelerated recovery of postoperative cognitive function.
我们进行了一项随机、双盲研究,以验证我们的假设,即腰骶部阻滞作为预防性镇痛用于下腰痛手术可能会加速术后行走锻炼的时间,并减少术后镇痛药物的使用,从而更快地恢复认知功能。
我们的研究纳入了 51 名年龄>70 岁、ASA 身体状况 1-3 级的老年患者,他们在全身麻醉下接受腰骶部手术。在麻醉诱导和气管插管后,研究组(B 组)患者在手术切口前 15 分钟注射单纯 0.5%布比卡因[10ml×身高(m)]作为骶管阻滞,而对照组(C 组)患者则给予生理盐水。手术后,患者可使用静脉患者自控镇痛(IV PCA)、芬太尼进行术后镇痛。我们评估了手术前后的简易精神状态检查(MMSE)评分、术后视觉模拟评分(VAS)值、术后和术后 3 天内芬太尼的消耗量以及术后开始行走锻炼的时间。
B 组患者的 VAS 值在整个术后 48 小时内明显低于 C 组(p<0.005),B 组患者开始行走锻炼的时间明显早于 C 组[C 组的平均(标准差)为 70.2(14.3),B 组为 61.9(7.6);p=0.0133]。术后 24 小时,B 组患者的认知功能水平高于 C 组。
腰骶部阻滞作为预防性镇痛可缩短术后开始行走锻炼的时间,加快术后认知功能的恢复。