Pye Stephen R, Devakumar Vinodh, Boonen Steven, Borghs Herman, Vanderschueren Dirk, Adams Judith E, Ward Kate A, Bartfai Gyorgy, Casanueva Felipe F, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Han Thang S, Huhtaniemi Ilpo T, Kula Krzysztof, Lean Michael E J, Pendleton Neil, Punab Margus, Silman Alan J, Wu Frederick C W, O'Neill Terence W
ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
Calcif Tissue Int. 2010 Mar;86(3):211-219. doi: 10.1007/s00223-009-9330-y. Epub 2010 Jan 19.
We examined the distribution of quantitative heel ultrasound (QUS) parameters in population samples of European men and looked at the influence of lifestyle factors on the occurrence of these parameters. Men aged between 40 and 79 years were recruited from eight European centers and invited to attend for an interviewer-assisted questionnaire, assessment of physical performance, and quantitative ultrasound (QUS) of the calcaneus (Hologic; Sahara). The relationships between QUS parameters and lifestyle variables were assessed using linear regression with adjustments for age, center, and weight. Three thousand two hundred fifty-eight men, mean age 60.0 years, were included in the analysis. A higher PASE score (upper vs. lower tertile) was associated with a higher BUA (β coefficient = 2.44 dB/Mhz), SOS (β = 6.83 m/s), and QUI (β = 3.87). Compared to those who were inactive, those who walked or cycled more than an hour per day had a higher BUA (β = 3.71 dB/Mhz), SOS (β = 6.97 m/s), and QUI (β = 4.50). A longer time to walk 50 ft was linked with a lower BUA (β = -0.62 dB/Mhz), SOS (β = -1.06 m/s), and QUI (β = -0.69). Smoking was associated with a reduction in BUA, SOS, and QUI. There was a U-shaped association with frequency of alcohol consumption. Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men.
我们研究了欧洲男性人群样本中定量足跟超声（QUS）参数的分布情况，并探讨了生活方式因素对这些参数出现的影响。年龄在40至79岁之间的男性从八个欧洲中心招募而来，并被邀请参加由访谈员协助的问卷调查、身体机能评估以及跟骨定量超声检查（Hologic；Sahara）。使用线性回归评估QUS参数与生活方式变量之间的关系，并对年龄、中心和体重进行了调整。分析纳入了3258名男性，平均年龄60.0岁。较高的PASE评分（上三分位数与下三分位数相比）与较高的宽带超声衰减（BUA）（β系数 = 2.44 dB/Mhz）、声速（SOS）（β = 6.83 m/s）和定量超声指数（QUI）（β = 3.87）相关。与不活动的人相比，每天步行或骑自行车超过一小时的人具有更高的BUA（β = 3.71 dB/Mhz）、SOS（β = 6.97 m/s）和QUI（β = 4.50）。步行50英尺所需的时间越长，与较低的BUA（β = -0.62 dB/Mhz）、SOS（β = -1.06 m/s）和QUI（β = -0.69）相关。吸烟与BUA、SOS和QUI的降低有关。饮酒频率呈U形关联。改变生活方式，包括增加体育活动和戒烟，可能有助于优化中年及老年欧洲男性的骨骼强度并降低骨折风险。
