ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, UK.
Calcif Tissue Int. 2010 Mar;86(3):211-9.
We examined the distribution of quantitative heel ultrasound (QUS) parameters in population samples of European men and looked at the influence of lifestyle factors on the occurrence of these parameters. Men aged between 40 and 79 years were recruited from eight European centers and invited to attend for an interviewer-assisted questionnaire, assessment of physical performance, and quantitative ultrasound (QUS) of the calcaneus (Hologic; Sahara). The relationships between QUS parameters and lifestyle variables were assessed using linear regression with adjustments for age, center, and weight. Three thousand two hundred fifty-eight men, mean age 60.0 years, were included in the analysis. A higher PASE score (upper vs. lower tertile) was associated with a higher BUA (beta coefficient = 2.44 dB/ Mhz), SOS (beta = 6.83 m/s), and QUI (beta = 3.87). Compared to those who were inactive, those who walked or cycled more than an hour per day had a higher BUA (beta = 3.71 dB/Mhz), SOS (beta = 6.97 m/s), and QUI (beta = 4.50). A longer time to walk 50 ft was linked with a lower BUA (beta = -0.62 dB/ Mhz), SOS (beta = -1.06 m/s), and QUI (beta = -0.69). Smoking was associated with a reduction in BUA, SOS, and QUI. There was a U-shaped association with frequency of alcohol consumption. Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men.
我们研究了欧洲男性人群样本中定量足跟超声（QUS）参数的分布，并探讨了生活方式因素对这些参数发生的影响。从 8 个欧洲中心招募了年龄在 40 至 79 岁之间的男性，并邀请他们参加访谈式问卷调查、身体机能评估以及跟骨定量超声（Hologic；Sahara）检查。使用线性回归分析，在调整年龄、中心和体重后，评估 QUS 参数与生活方式变量之间的关系。3258 名男性，平均年龄 60.0 岁，纳入分析。较高的 PASE 评分（上三分位与下三分位相比）与较高的 BUA（β系数=2.44 dB/Mhz）、SOS（β=6.83 m/s）和 QUI（β=3.87）相关。与不活跃者相比，每天步行或骑车超过 1 小时的人 BUA（β=3.71 dB/Mhz）、SOS（β=6.97 m/s）和 QUI（β=4.50）较高。行走 50 英尺所需的时间较长与较低的 BUA（β=-0.62 dB/Mhz）、SOS（β=-1.06 m/s）和 QUI（β=-0.69）相关。吸烟与 BUA、SOS 和 QUI 降低有关。饮酒频率与 BUA、SOS 和 QUI 呈 U 型关联。生活方式的改变，包括增加身体活动和戒烟，可能有助于优化骨骼强度，降低中年和老年欧洲男性骨折的风险。
