Al-Sarraf M D
Williams Beaumont Hospital, Royal Oak, Michigan, USA.
Gulf J Oncolog. 2007 Jul(2):8-16.
Concurrent chemo-radiotherapy has become the standard treatment for patients with locally advanced head and neck cancers. In surgically operated patients post-operative concurrent chemo-radiotherapy is the standard of care. For organ/speech preservation and in patients who are not surgically operable the standard of care is concurrent chemo-radiotherapy. In patients with locally advanced NPC although concurrent chemo-radiotherapy was superior to RT only, the standard of care is concurrent chemo-radiotherapy followed by three courses of adjuvant combination chemotherapy. Single daily fraction irradiation is the standard of care when given concomitant with chemotherapy. Although, single agent cisplatin given on every three weeks schedule is the standard of care, this could be replaced safely and as effectively with weekly carboplatin given with RT with much less side effects and with similar efficacy.
同步放化疗已成为局部晚期头颈癌患者的标准治疗方法。对于接受手术治疗的患者，术后同步放化疗是标准的治疗方案。对于器官/言语保留以及无法进行手术的患者，标准治疗方案是同步放化疗。在局部晚期鼻咽癌患者中，尽管同步放化疗优于单纯放疗，但标准治疗方案是同步放化疗后进行三个疗程的辅助联合化疗。与化疗同时进行时，每日单次分割照射是标准的治疗方案。虽然每三周一次的顺铂单药治疗是标准的治疗方案，但可以安全有效地用每周一次的卡铂与放疗联合使用来替代，副作用小得多且疗效相似。
