Wang Jin, Liu Qing-lian, Yang Chao-mei
Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, Sichuan, China.
Zhongguo Yi Miao He Mian Yi. 2009 Jun;15(3):219-22.
To analyze the characteristic and regular patterns of AEFI after Supplementary Immunization Activity (SIAs) of Measles Attenuated Live Vaccine in Sichuan Province in 2007-2008, to discuss the safety of MV SIAs and measures of reducing occurrence of AEFI.
The descriptive epidemiology analysis on related indexes were conducted.
59 cases of serious AEFI were reported in MV SIAs in 2007-2008. The incidence rate was 4.13/million dosage, and male was higher than female; The incidence between age groups was no significant statistics differences (chi2 = 0.53, P>0.05); people occurrencing serious AEFI within 2 days after vaccination accounted for 3/4. Allergic reaction dominated the clinical damage. Most of the cases were cured.
Incidence of serious AEFI after MV SIAs was low. It is safe to conduct MV SIAs. Children of all age groups should be observed within 2 day after vaccination. To guarantee the smooth conduct of MV SIAs, we should strengthen AEFI surveillance and improve the skill for handling with serious AEFI.
分析四川省2007 - 2008年麻疹减毒活疫苗强化免疫活动（SIAs）后疑似预防接种异常反应（AEFI）的特征和规律，探讨麻疹疫苗强化免疫活动的安全性及降低AEFI发生的措施。
对相关指标进行描述性流行病学分析。
2007 - 2008年麻疹疫苗强化免疫活动报告严重AEFI 59例，发生率为4.13/百万剂次，男性高于女性；各年龄组间发生率差异无统计学意义（χ2 = 0.53，P>0.05）；接种疫苗后2天内发生严重AEFI者占3/4。临床损害以过敏反应为主。多数病例治愈。
麻疹疫苗强化免疫活动后严重AEFI发生率低，开展麻疹疫苗强化免疫活动是安全的。各年龄组儿童接种疫苗后2天内应进行观察。为保证麻疹疫苗强化免疫活动的顺利开展，应加强AEFI监测，提高严重AEFI的处置能力。
