[用上海-191株毒种制备的麻疹减毒活疫苗的安全性及免疫原性]

[Safety and immunogenicity of measles attenuated live vaccine prepared by master seed lot vaccine of Shanghai-191 strain].

作者信息

Zhang Shu-Jun, Xiao Qi-You, Li Fang-Jun

机构信息

Human provincial Center for Disease Control and Prevention, Changsha 410005, Hunan, China.

出版信息

Zhongguo Yi Miao He Mian Yi. 2009 Oct;15(5):423-5.

PMID:20084967

Abstract

OBJECTIVE

To evaluate the safety and immunogenicity of a new measles vaccine prepared by master seed lot original vaccine of Shanghai-191 strain.

METHODS

According to selection and exclusion criteria, 8-10-month healthy children, who have no history of measles, measles vaccine inoculation and vaccination contraindication were selected. The children selected were vaccinated 0.5 ml measles attenuate live vaccine prepared by master seed lot vaccine of the Shanghai-191 strain. They were observed the local and systemic response in 30 min and 6h, 24h, 48h, 72h, 7d, 14d, 21d, 28d after inoculation, and immune serum were collected before immunization and after 28 days. Measles virus antibody positive rate and geometric mean titer (GMT) were detected by hemagglutination inhibition.

RESULTS

There were not serious adverse reactions. Measles virus antibodies in serum positive rate was 100% after 28 days of immunization, and measles virus antibody GMT was 1:50.66.

CONCLUSION

New measles vaccine prepared by master seed lot original vaccine of the Shanghai-191 strain at 8-10-month children was safe and immunogenicity.

摘要

目的

评价以上海-191株毒种原液制备的新型麻疹疫苗的安全性和免疫原性。

方法

根据入选和排除标准，选取8至10月龄无麻疹病史、无麻疹疫苗接种史及无接种禁忌的健康儿童。给入选儿童接种0.5ml由上海-191株毒种制备的麻疹减毒活疫苗。接种后30分钟、6小时、24小时、48小时、72小时、7天、14天、21天、28天观察局部和全身反应，并于免疫前及免疫后28天采集免疫血清。采用血凝抑制试验检测麻疹病毒抗体阳性率和几何平均滴度（GMT）。