Department of Paediatrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Vaccine. 2011 Apr 18;29(18):3507-10. doi: 10.1016/j.vaccine.2009.10.106. Epub 2009 Nov 10.
The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis reaction was estimated to be 6.5 per million for attenuated measles vaccine. Among 14.3 million vaccination practices, 1 case each of acute disseminated encephalomyelitis (ADEM) and idiopathic thrombocytopenic purpura (ITP) and 28 cases of Henoch-Schonlein purpura (HSP) were reported. The total incidence of serious adverse events after vaccination was 2.14 per million doses.
本研究旨在描述中国内地减毒麻疹疫苗的不良反应。我们对大规模麻疹免疫实践后的不良反应进行了前瞻性随访，将其分为两类：过敏反应和严重不良反应。减毒麻疹疫苗的过敏反应发生率估计为每百万剂 6.5 例。在 1430 万次接种中，分别报告了 1 例急性播散性脑脊髓炎（ADEM）和特发性血小板减少性紫癜（ITP）病例，以及 28 例过敏性紫癜（HSP）病例。接种后严重不良事件的总发生率为每百万剂 2.14 例。
