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2007 年至 2008 年中国四川省大规模疫苗接种运动中报告的麻疹疫苗不良反应事件。

Measles vaccine adverse events reported in the mass vaccination campaign of Sichuan province, China from 2007 to 2008.

机构信息

Department of Paediatrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

出版信息

Vaccine. 2011 Apr 18;29(18):3507-10. doi: 10.1016/j.vaccine.2009.10.106. Epub 2009 Nov 10.

Abstract

The aim of this study was to characterize the adverse events of attenuated measles vaccine in mainland China. We carried out prospective follow-up of adverse events after mass measles immunization practices, categorizing them into two groups: allergic reactions and serious adverse events. The incidence of anaphylaxis reaction was estimated to be 6.5 per million for attenuated measles vaccine. Among 14.3 million vaccination practices, 1 case each of acute disseminated encephalomyelitis (ADEM) and idiopathic thrombocytopenic purpura (ITP) and 28 cases of Henoch-Schonlein purpura (HSP) were reported. The total incidence of serious adverse events after vaccination was 2.14 per million doses.

摘要

本研究旨在描述中国内地减毒麻疹疫苗的不良反应。我们对大规模麻疹免疫实践后的不良反应进行了前瞻性随访,将其分为两类:过敏反应和严重不良反应。减毒麻疹疫苗的过敏反应发生率估计为每百万剂 6.5 例。在 1430 万次接种中,分别报告了 1 例急性播散性脑脊髓炎(ADEM)和特发性血小板减少性紫癜(ITP)病例,以及 28 例过敏性紫癜(HSP)病例。接种后严重不良事件的总发生率为每百万剂 2.14 例。

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