非人灵长类动物减毒麻疹疫苗的多中心安全性和免疫原性试验。
Multicenter Safety and Immunogenicity Trial of an Attenuated Measles Vaccine for NHP.
作者信息
Yee Joann L, McChesney Michael B, Christe Kari L
机构信息
California National Primate Research Center, University of California, Davis, California, USA.
出版信息
Comp Med. 2015 Oct;65(5):448-54.
Measles is a highly contagious viral disease in NHP. The infection can range from asymptomatic to rapidly fatal, resulting in significant morbidity and mortality in captive populations. In addition to appropriate quarantine practices, restricted access, the immunization of all personnel in contact with NHP, and the wearing of protective clothing including face masks, measles immunization further reduces the infection risk. Commercially available measles vaccines are effective for use in NHP, but interruptions in their availability have prevented the implementation of ongoing, consistent vaccination programs. This need for a readily available vaccine led us to perform a broad, multicenter safety and immunogenicity study of another candidate vaccine, MVac (Serum Institute of India), a monovalent measles vaccine derived from live Edmonston-Zagreb strain virus that had been attenuated after 22 passages on human diploid cells.
麻疹是一种在非人灵长类动物中具有高度传染性的病毒性疾病。感染情况从无症状到迅速致命不等，会在圈养种群中导致显著的发病率和死亡率。除了采取适当的检疫措施、限制进入、对所有接触非人灵长类动物的人员进行免疫以及穿戴包括口罩在内的防护服外，麻疹免疫进一步降低了感染风险。市售的麻疹疫苗可有效用于非人灵长类动物，但疫苗供应的中断阻碍了持续、一致的疫苗接种计划的实施。对现成疫苗的这种需求促使我们对另一种候选疫苗MVac（印度血清研究所）进行了一项广泛的多中心安全性和免疫原性研究，MVac是一种单价麻疹疫苗，源自埃德蒙斯顿-萨格勒布活病毒株，该病毒株在人二倍体细胞上经过22代传代后已减毒。
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